Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes

Figure 1 NJE protects islets from STZ-induced destruction. A: ICR mice were intraperitoneally injected daily with NJE at 125 mg/kg for 3 d and then injected with STZ (80 mg/kg) intravenously. Levels of fasting glucose and insulin were determined; B: Pancreases were obtained from normal controls (a, e), and STZ-injected (b, f), NJE-injected (c, g), and NJE and STZ-injected mice (d, h). Islets and adjoining exocrine regions were counterstained with HE (a-d). Islets were labeled with insulin antibody and peroxidase-labeled anti-rabbit IgG (e-h); C: Nuclear extracts from pancreatic tissues were prepared 30 min after STZ injection, and NF-κB DNA binding was analyzed using electrophoretic mobility shift assay. ^bP < 0.01 vs untreated control; ^dP < 0.01 vs STZ-injected group. NJE: Nardostachys jatamansi extract; STZ: Streptozotocin; NF-κB: Nuclear factor κB.