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©2010 Baishideng.
World J Gastroenterol. Jul 7, 2010; 16(25): 3187-3195
Published online Jul 7, 2010. doi: 10.3748/wjg.v16.i25.3187
Published online Jul 7, 2010. doi: 10.3748/wjg.v16.i25.3187
Table 1 Characteristics of excluded studies
Author | Location | Study design | Participants | TPMT genotypes was determined | Dose of thiopurine | Reason for exclusion |
Cao et al[6], 2009 | China | Cross-sectional | 43 treated IBD patients | TPMT*2, TPMT*3A | AZA 1.35 mg/kg per day | Incomplete data |
TPMT*3B, TPMT*3C | ||||||
Takatsu et al[7], 2009 | Japan | Cross-sectional | 147 treated IBD patients | TPMT*2, TPMT*3B | AZA 25 mg/d | Incomplete data |
TPMT*3C, TPMT*8 | or 75 mg/d | |||||
or 100 mg/d | ||||||
Uchiyama et al[8], 2009 | Japan | Cross-sectional | 16 treated IBD patients with ADRs | TPMT*2, *3A, *3B | AZA < 50 mg/d | Incomparable control group |
TPMT*3C, *3D, *4 | or 6-MP < 30 mg/d | No definition of ADRs | ||||
TPMT*5, *6, *7, *8 | Pediatric patients included | |||||
Ban et al[9], 2008 | Japan | Case-control | 70 treated IBD patients | TPMT*2, TPMT*3A | Not mentioned | Dose of thiopurine not mentioned |
41 healthy controls | TPMT*3B, TPMT*3C | |||||
Gearry et al[10], 2003 | New Zealand | Case-control | 56 treated IBD patients with ADRs | TPMT*2, TPMT*3A | Not mentioned | Dose of thiopurine not mentioned |
50 treated IBD patients without ADRs | TPMT*3B, TPMT*3C | |||||
Regueiro et al[11], 2002 | USA | Cross-sectional | 71 treated CD patients | TPMT*3A, TPMT*3B | AZA 2.35 mg/kg per day | 38 patients had determination of TPMT by phenotype |
TPMT*3C | or 1.28 mg/kg per day | |||||
Evans et al[12], 2001 | USA | Cross-sectional | 23 treated patients with ADRs | TPMT*2, TPMT*3A | AZA 32 mg/m2 per week | Non-IBD patients |
TPMT*3B, TPMT*3C | or 175 mg/m2 per week | |||||
or 280 mg/m2 per week | ||||||
Naughton et al[13], 1999 | UK | Cross-sectional | 15 treated IBD patients | TPMT*2, TPMT*3A | Not mentioned | Dose of thiopurine not mentioned |
TPMT*3B, TPMT*3C |
- Citation: Dong XW, Zheng Q, Zhu MM, Tong JL, Ran ZH. Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease. World J Gastroenterol 2010; 16(25): 3187-3195
- URL: https://www.wjgnet.com/1007-9327/full/v16/i25/3187.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i25.3187