Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?

Table 3 Statistical performance of combinations of two tests in the high- and low-risk populations at the cut-off provided by the manufacturer

Test	% (95% CI)			(%)
	Sensitivity	Specificity	AU ROC	PPV	NPV
High-risk
IgA a-DGP + IgA a-tTG	93.6 (84.5-98.2)	99.0 (94.4-99.8)	0.963 (0.921-0.986)	98.4	95.9
IgG a-DGP + IgA a-tTG	90.5 (80.4-96.4)	100.0 (96.3-100)	0.952 (0.907-0.980)	100.0	94.0
DGP Dual + IgA a-tTG	92.0 (82.4-97.3)	100.0 (96.3-100)	0.960 (0.917-0.985)	100.0	95.0
DGP/tTG Screen + IgA a-tTG	95.2 (86.7-99.0)	100.0 (96.3-100.0)	0.976 (0.939-0.994)	100.0	96.9
IgA a-DGP + DGP/tTG Screen	98.4 (91.4-99.7)	96.9 (91.3-99.3)	0.977 (0.940-0.994)	95.4	99.0
IgG a-DGP + IgA a-DGP	95.2 (86.7-99.0)	100.0 (96.3-100.0)	0.976 (0.939-0.994)	100.0	97.0
IgA a-DGP + DGP Dual	96.8 (89.0-99.5)	100.0 (96.3-100.0)	0.984 (0.951-0.997)	100.0	98.0
IgG a-DGP + DGP Dual	95.2 (86.7-99.0)	100.0 (96.3-100.0)	0.976 (0.939-0.994)	100.0	97.0
IgG a-DGP + DGP/tTG Screen	95.2 (86.7-99.0)	100.0 (96.3-100.0)	0.976 (0.939-0.994)	100.0	97.0
DGP Dual + DGP/tTG Screen	96.8 (89.0-99.5)	100.0 (96.3-100.0)	0.984 (0.951-0.997)	100.0	98.0
Low-risk
IgA a-DGP + IgA a-tTG	72.2 (46.5-90.2)	99.8 (98.9-100.0)	0.860 (0.827-0.889)	92.9	99.0
IgG a-DGP + IgA a-tTG	66.7 (41.0-86.6)	100.0 (99.3-100.0)	0.833 (0.798-0.864)	100.0	98.8
DGP Dual + IgA a-tTG	72.2 (46.5-90.2)	99.8 (99.3-100.0)	0.861 (0.828-0.890)	92.8	99.0
DGP/tTG Screen + IgA a-tTG	72.2 (46.5-90.2)	98.8 (97.4-99.6)	0.855 (0.822-0.884)	68.4	99.0
IgA a-DGP + DGP/tTG Screen	82.3 (56.6-96.0)	99.0 (97.7-99.7)	0.907 (0.878-0.930)	73.6	99.4
IgG a-DGP + IgA a-DGP	70.6 (44.1-89.6)	100.0 (99.3-100.0)	0.853 (0.819-0.882)	100.0	99.0
IgA a-DGP + DGP Dual	76.5 (50.1-93.0)	99.6 (98.6-99.9)	0.880 (0.849-0.907)	86.6	99.2
IgG a-DGP + DGP Dual	70.6 (44.1-89.6)	99.0 (97.7-99.7)	0.848 (0.814-0.878)	70.5	99.0
IgG a-DGP + DGP/tTG Screen	70.6 (44.1-89.6)	99.4 (98.3-99.9)	0.850 (0.816-0.880)	80.0	99.0
DGP Dual + DGP/tTG Screen	76.5 (89.0-99.5)	99.0 (96.3-100.0)	0.877 (0.846-0.904)	72.2	99.2

The statistical performance of the 10 combinations assessed is reported, considering a result to be positive if both tests of the combination have concentrations above the cutoff.