Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis

Table 2 Allelic and genotypic frequencies of the VDR FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) polymorphisms in controls and liver cirrhosis patients n (%)

VDR	Control subjects (n = 236)	Liver cirrhosis (n = 240)	OR	95% CI	P1
	F = 0.646	F = 0.665	1	Ref.
FokI	f = 0.354	f = 0.335	1.085	0.831-1.417	NS
	B = 0.392	B = 0.421	1	Ref.
BsmI	b = 0.608	b = 0.579	1.127	0.870-1.460	NS
	A = 0.570	A = 0.590	1	Ref.
ApaI	a = 0.430	a = 0.410	1.084	0.838-1.402	NS
	T = 0.608	T = 0.579	1	Ref.
TaqI	t = 0.392	t = 0.421	0.887	0.685-1.149	NS
	F/F = 104 (44.1)	F/F = 105 (43.8)	1	Ref.
FokI	F/f = 97 (41.1)	F/f = 109 (45.4)	1.113	0.758-1.635	NS
	f/f = 35 (14.8)	f/f = 26 (10.8)	0.736	0.416-1.303	NS
	B/B = 41 (17.4)	B/B = 40 (16.7)	1	Ref.
BsmI	B/b = 103 (43.6)	B/b = 122 (50.8)	1.214	0.732-2.014	NS
	b/b = 92 (39.0)	b/b = 78 (32.5)	0.869	0.513-1.473	NS
	A/A = 76 (32.2)	A/A = 80 (33.3)	1	Ref.
ApaI	A/a = 117 (49.6)	A/a = 123 (51.3)	0.999	0.668-1.494	NS
	a/a = 43 (18.2)	a/a = 37 (15.4)	0.817	0.477-1.400	NS
	T/T = 89 (37.7)	T/T = 76 (31.7)	1	Ref.
TaqI	T/t = 109 (46.2)	T/t = 126 (52.5)	1.354	0.909-2.017	NS
	t/t = 38 (16.1)	t/t = 38 (15.8)	1.171	0.681-2.013	NS

The odds ratios were constructed with the wild type for each polymorphism as the reference. The statistical analysis was carried out using the Pearson χ² test.

¹Pearson χ² test; OR: Odds ratio; CI: Confidence interval; VDR: Vitamin D receptor.