CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis

doi:10.3748/wjg.v16.i23.2873

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Jun 21, 2010 (publication date) through Dec 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2010; 16(23): 2873-2880
Published online Jun 21, 2010. doi: 10.3748/wjg.v16.i23.2873

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Figure 4 Effects of CXCR4 antagonist on migration and cytokine production of isolated PBMCs. To mimic the in vivo inflammatory response, the PBMCs were pre-activated with PHA. Migration of PBMCs (A) and levels of TNF-α (B), IL-6 (C), and IFN-γ ( D) in PBMCs are shown. Six wells were studied in each experimental group. Results are mean ± SE. ^aP < 0.05, chemokine stromal cell-derived factor-1 (CXCL12) group vs control group; ^cP < 0.05, AMD3100 group vs CXCL12 group.

Citation: Xia XM, Wang FY, Xu WA, Wang ZK, Liu J, Lu YK, Jin XX, Lu H, Shen YZ. CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis. World J Gastroenterol 2010; 16(23): 2873-2880
URL: https://www.wjgnet.com/1007-9327/full/v16/i23/2873.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i23.2873