CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis

Figure 3 Effects of CXCR4 antagonist on colonic epithelial apoptosis in mice. Colitis was induced by administration of 5% DSS for 7 d. Tissue sections were stained with Hoechst-33342. A: Sporadic apoptotic cells were observed in intestinal segments from the control group; B: Clustered apoptotic cells were observed in tissue sections from the colitis group; C: Treatment with CXCR4 antagonist AMD3100 obviously decreased epithelial apoptosis; D: The numbers of apoptotic cells in intestinal segments. Eight mice were studied in each experimental group. Results are mean ± SE. ^aP < 0.05 vs control group; ^cP < 0.05 vs DSS + PBS group. Original magnification, × 200.