Endoscopic ultrasound for the diagnosis of chronic pancreatitis

Table 2 Test performance of endoscopic ultrasound in comparative studies

Study	Gold standard	Cut-point	Overall test performance		Minimal change CP test performance
			Sensitivity	Specificity	Sensitivity	Specificity
Buscail et al[11]	Composite	None	89% (39/44)	100% (18/18)	NR	NR
Nattermann et al[4]	ERCP	None	98% (50/51)	63% (27/43)	88% (7/8)	63% (27/43)
Wiersema et al[2]	ERCP	≥ 3	100% (19/19)	79% (38/48)	100% (18/18)	79% (38/48)
Catalano et al[3]	ERCP	≥ 3	86% (31/36)	95% (42/44)	82% (22/27)	95% (42/44)
Sahai et al[8]	ERCP	≥ 3	63% NR	68% NR	NR	NR
Hastier et al[25]	ERCP	None	93% (13/14)	NR	NR	NR
Hollerbach et al[36]	ERCP	Grade 0-3	97% (30/31)	67% (4/6)	95% (20/21)	67% (4/6)
Wiersema et al[2]	Secretin ID-PFT	≥ 3	67% (6/9)	29% (2/7)	67% (6/9)	29% (2/7)
Catalano et al[3]	Secretin ID-PFT	≥ 3	84% (21/25)	78% (43/55)	NR	NR
Raimondo et al[13]	CCK PFT	≥ 4	43% (3/7)	50% (4/8)	NR	NR
Chowdhury et al[14]	Secretin PFT	≥ 3	71% (5/7)	35% (5/14)	71% (5/7)	35% (5/14)
Stevens et al[15]	Secretin PFT	≥ 3	68% (34/50)	79% (30/38)	NR	NR
Stevens et al[16]	Secretin PFT	≥ 4	71% (17/24)	92% (24/26)	NR	NR
Stevens et al[16]	CCK PFT	≥ 4	63% (15/24)	85% (22/26)	NR	NR
Chong et al[19]	Histology	≥ 3	NR	NR	83% (30/36)	80% (4/5)
Varadarajulu et al[18]	Histology	≥ 4	91% (19/21)	86% (18/21)	91% (19/21)	86% (18/21)
Gupta et al[20]	Histology	≥ 3	71% (10/14)	100% (1/1)	71% (10/14)	100% (1/1)
Albashir et al[21]	Histology	≥ 4	75% (12/16)	NR	NR	NR
Bhutani et al[49]	Histology (Autopsy)	≥ 3	100% (10/10)	100% (1/1)	100% (10/10)	100% (1/1)
Kahl et al[22]	Baseline or repeat ERCP	≥ 1	100% (114/114)	NR	NR	NR
Morris-Stiff et al[24]	Radiographic progression	None	100% (13/13)	NR	100% (13/13)	NR

Calc: Calcification; CCK: Cholecystokinin; NR: Not reported or calculable; PFT: Pancreatic function test; ID-PFT: Intraductal pancreatic function test.