Prophylactic uses of integrin CD18-βA peptide in a murine polymicrobial peritonitis model

Figure 3 A predicted model of the amphipathic helix sequence at CD18-βA that binds bacterial endotoxin. Shown is the polypeptide sequence of the CD18-βA domain of leukocyte β2 integrin, and the two LPS-binding sites are colored green and red. CD18-βA peptide is derived from the red binding site. The underlined portion of CD18-βA peptide demonstrates a feature of the amphipathic helix, as revealed by the helical wheel diagram.