Prophylactic uses of integrin CD18-βA peptide in a murine polymicrobial peritonitis model

Figure 1 CD18-βA peptide protects mice against cecal ligation and puncture (CLP)-induced lethality and inflammatory responses. A: Mice were injected with either sterile saline or CD18-βA peptide intraperitoneally at 12 h intervals beginning 2 h after CLP (as indicated by arrows), and were monitored continually over 48 h. There was statistically significant improvement in survival of septic shock mice that received CD18-βA injection (P < 0.01), compared to those that received saline. n = 8 for each experimental groups; B: Measurement of endotoxin activity and tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels in blood circulation. Injection of CD18-βA peptide achieved significant reductions in endotoxin activity at 24 h, and reductions in TNF-α and IL-6 at 12 and 24 h after CLP. 12 h, n = 5 and 24 h, n = 6 for each experimental group. ^aP < 0.05, ^bP < 0.01 vs saline group (one-way ANOVA). Error bars represent mean ± SD.