AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas

Figure 1 α-methylacyl CoA racemase (AMACR) expression in colorectal adenomas is related to the grade of dysplasia. A: Cumulative results from all dysplastic areas within each one of the 55 cases examined. Histology columns: white = absence, blue = presence of the indicated histological pattern. AMACR column: white = negative, grey = weak, black = strong staining; B and C: Case 44, as listed in A. In this adenoma with high grade dysplasia (HE staining), AMACR staining is restricted to the in situ component (IS) with severely dysplastic (S) adjacent glands showing negative or focal weak immunoreactivity. Bars: 100 microns.