AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas

Table 2 AMACR expression in sporadic colorectal adenomas n (%)

Vienna classification of GI neoplasia	Biologic potential	Staining
		Negative	Weak	Strong	Subtotal positive	Total
Low grade (n = 16)	Mild	13 (81.3)	3 (18.8)	0 (0)	3 (18.8)	16
	moderate
High grade (n = 35)	Severe	9 (60)	6 (40)	0 (0)	6 (40)	15
	In situ carcinoma	2 (11.8)	3 (17.6)	12 (70.6)1	15 (88.2)	17
	Intramucosal carcinoma	1	0	2	2	3
Infiltrative carcinoma (n = 4)	Submucosal carcinoma	1	1	2	3	4
		26 (47.3)	13 (23.7)	16 (29)	29 (52.7)	55

¹In 3 cases (#48, 49, 52 in Figure 1A) higher grade focus and focus of most intense staining did not match, as described in Materials and Methods, Interpretation. AMACR: α-methylacyl CoA racemase; GI: Gastrointestinal.