Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn&rsquo;s disease patients

doi:10.3748/wjg.v16.i2.176

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Jan 14, 2010 (publication date) through Mar 7, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2010; 16(2): 176-183
Published online Jan 14, 2010. doi: 10.3748/wjg.v16.i2.176

Table 5 Genotype-specific CD odds ratios¹ (with 95% CI) for combinations of variants in IBD5, IL23R and ATG16L1

	IL23R rs1004189		IL23R rs2201841		ATG16L1
	GG	GA+AA	TT+TC	CC	AA+AG	GG
IGR2198a_1
GG	1	1.43 (0.80-2.53)	1	4.83 (1.52-15.37)^a	1	1.71 (0.94-3.09)
GC+CC	1.45 (0.84-2.48)	2.44 (1.43-4.15)^a	1.58 (1.11-2.24)^a	3.66 (1.81-7.41)^a	1.60 (1.07-2.38)^a	2.38 (1.46-3.87)^a
IGR2096a_1
GG	1	1.55 (0.88-2.73)	1	4.03 (1.39-11.62)^a	1	1.63 (0.91-2.92)
GT+TT	1.49 (0.87-2.56)	2.41 (1.42-4.09)^a	1.50 (1.06-2.13)^a	3.71 (1.80-7.67)^a	1.50 (1.01-2.24)^a	2.32 (1.42-3.79)^a

¹IGR2198a_1, IGR2096a_1 and IL23R rs1004189: OR relative to wild type genotype; ATG16L1 and IL23R rs2201841: OR relative to wild and heterozygous genotypes together.

^aP < 0.05 vs controls.

Citation: Csöngei V, Járomi L, Sáfrány E, Sipeky C, Magyari L, Faragó B, Bene J, Polgár N, Lakner L, Sarlós P, Varga M, Melegh B. Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients. World J Gastroenterol 2010; 16(2): 176-183
URL: https://www.wjgnet.com/1007-9327/full/v16/i2/176.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i2.176