Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn&rsquo;s disease patients

doi:10.3748/wjg.v16.i2.176

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2010; 16(2): 176-183
Published online Jan 14, 2010. doi: 10.3748/wjg.v16.i2.176

Table 4 Genotype-specific CD odds ratios¹ (with 95% CI) for combinations of variants in IL23R, ATG16L1 and CARD15

	CARD15 R702W		CARD15 G908R		CARD15 L1007fs		CARD15 status		ATG16L1
	CC	CT+TT	GG	GC+CC	- -	- insC+insC insC	-	+	AA+AG	GG
IL23R rs1004189
GG	1	2.35 (1.03-5.34)^a	1	1.55 (0.46-5.21)	1	2.85 (1.28-6.35)^a	1	2.100 (1.17-3.76)^a	1	1.16 (0.68-1.99)
GA+AA	1.56 (1.12-2.19)^a	3.18 (1.45-6.97)^a	1.51 (1.09-2.09)^a	3.23 (0.99-10.57)	1.57 (1.12-2.20)^a	3.40 (1.69-6.82)^a	1.50 (1.04-2.16)^a	3.33 (1.96-5.67)^a	1.34 (0.92-1.95)	2.51 (1.55-4.08)^a
IL23R rs2201841
TT+TC	1	2.25 (1.26-4.03)^a	1	1.49 (0.62-3.59)	1	2.43 (1.42-4.18)^a	1	2.12 (1.42-3.16)^a	1	1.48 (1.03-2.14)^a
CC	3.04 (1.67-5.57)^a	4.75 (0.53-42.81)	2.69 (1.49-4.86)^a	NC	2.89 (1.57-5.32)^a	8.52 (1.04-69.74)^a	2.70 (1.42-5.15)^a	9.15 (2.05-40.74)^a	2.67 (1.31-5.44)^a	4.68 (1.72-12.78)^a
ATG16L1
AA+AG	1	2.20 (1.14-4.26)^a	1	1.44 (0.56-3.72)	1	2.37 (1.29-4.34)^a	1	2.12 (1.35-3.31)^a	-	-
GG	1.57 (1.09-2.25)^a	3.18 (1.11-9.08)^a	1.51 (1.06-2.14)^a	6.91 (0.83-57.92)	1.54 (1.07-2.22)^a	4.27 (1.54-11.79)^a	1.54 (1.04-2.27)^a	3.82 (1.86-7.86)^a	-	-

¹CARD15 R702W, G908R and L1007fs: OR relative to wild type genotype; CARD15 status: OR relative to - (wild type) group; ATG16L1: OR relative to wild and heterozygous genotypes together.

^aP < 0.05 vs controls.

Citation: Csöngei V, Járomi L, Sáfrány E, Sipeky C, Magyari L, Faragó B, Bene J, Polgár N, Lakner L, Sarlós P, Varga M, Melegh B. Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients. World J Gastroenterol 2010; 16(2): 176-183
URL: https://www.wjgnet.com/1007-9327/full/v16/i2/176.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i2.176