Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients

Table 3 Pairwise analysis of interactions of CARD15, IBD5 (IGR2198a_1), ATG16L1 and IL23R to risk of CD

Model	OR (95% CI)	P
IL23R rs1004189 * ATG16L1	1.51 (0.73-3.11)	0.26
IL23R rs2201841 * ATG16L1	1.01 (0.29-3.57)	0.99
IL23R rs1004189 * CARD15 status1	1.20 (0.54-2.67)	0.65
IL23R rs2201841 * CARD15 status	1.57 (0.30-8.31)	0.60
IL23R rs1004189 * IGR2198a_1	1.30 (0.71-2.36)	0.40
IL23R rs2201841 * IGR2198a_1	0.46 (0.12-1.75)	0.25
ATG16L1 * CARD15 status	1.49 (0.59-3.80)	0.40
ATG16L1 * IGR2198a_1	0.95 (0.45-2.00)	0.89
CARD15 status * IGR2198a_1	0.75 (0.33-1.71)	0.49

¹CARD15 status is denoted - (wild type) and + (at least one mutation in any of the three SNPs).

CD: Crohn’s disease.