Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn&rsquo;s disease patients

doi:10.3748/wjg.v16.i2.176

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2010; 16(2): 176-183
Published online Jan 14, 2010. doi: 10.3748/wjg.v16.i2.176

Table 2 Case-control genotypes and allele frequencies of variants in IL23R, ATG16L1, CARD15 and IBD5 n (%)

	CD (n = 315)	Controls (n = 314)	OR (95% CI)¹	P
IL23R (rs1004189)
GG	119 (37.8)	151 (48.1)
GA	152 (48.3)	140 (44.6)
GA+AA	196 (62.2)	163 (51.9)	1.50 (1.09-2.08)	0.013^a
AA	44 (14.0)	23 (7.3)	2.05 (1.20-3.50)	0.008^a
RAF	0.381	0.296		0.001^a
IL23R (rs2201841)
TT	131 (41.6)	152 (48.4)
TC	139 (44.1)	145 (46.2)
TC+CC	184 (58.4)	162 (25.8)	1.28 (0.93-1.76)	0.14
CC	45 (14.3)	17 (5.4)	2.97 (1.65-5.33)	< 0.001^a
RAF	0.363	0.285		0.003^a
ATG16L1 T300A (rs2241880)
AA	56 (17.8)	72 (22.9)
AG	151 (47.9)	163 (51.9)
AG+GG	259 (82.2)	242 (77.1)	1.45 (0.98-2.17)	0.06
GG	108 (34.3)	79 (25.2)	1.69 (1.19-2.41)	0.004^a
RAF	0.583	0.511		0.011^a
CARD15 R702W (rs2066844)
CC	275 (87.3)	294 (93.6)
CT	38 (12.1)	18 (5.7)
CT+TT	40 (12.7)	20 (6.4)	2.13 (1.19-3.80)	0.011^a
TT	2 (0.6)	2 (0.6)	0.62 (0.06-6.98)	0.70
RAF	0.067	0.035		0.011^a
CARD15 G908R (rs2066845)
GG	299 (94.9)	305 (97.1)
GC	16 (5.1)	9 (2.9)
GC+CC	16 (5.1)	9 (2.9)	1.65 (0.71-3.86)	0.24
CC	0 (0.0)	0 (0.0)	NC	NC
RAF	0.025	0.014		0.17
CARD15 L1007fs (rs2066847)
- -	264 (83.8)	291 (92.7)
- insC	42 (13.3)	23 (7.3)
- insC+insC insC	51 (16.2)	23 (7.3)	2.57 (1.51-4.36)	< 0.001^a
insC insC	9 (2.9)	0 (0.0)	NC	NC
RAF	0.095	0.037		< 0.001^a
CARD15 status²
-	220 (69.8)	262 (83.4)
+	95 (30.2)	52 (16.6)	2.17 (1.46-3.21)	< 0.001^a
IGR2198a_1 (rs11739135)
GG	91 (28.9)	120 (38.2)
GC	160 (50.8)	144 (45.9)
GC+CC	251 (79.7)	194 (61.8)	1.54 (1.10-2.15)	0.013^a
CC	64 (20.3)	50 (15.9)	1.32 (0.87-1.99)	0.19
RAF	0.457	0.389		0.014^a
IGR2096a_1 (rs12521868)
GG	94 (29.8)	120 (38.2)
GT	149 (47.3)	142 (45.2)
GT+TT	296 (94.0)	262 (83.4)	1.44 (1.03-2.02)	0.034^a
TT	72 (22.9)	52 (16.6)	1.45 (0.97-2.17)	0.07
RAF	0.465	0.392		0.009^a

¹Adjusted for age and gender;

²CARD15 status is denoted - (wild type) and + (at least one mutation in any of the three SNPs).

^aP < 0.05 vs controls.

RAF: Risk allele frequency; NC: Not calculated; OR: Odds ratio.

Citation: Csöngei V, Járomi L, Sáfrány E, Sipeky C, Magyari L, Faragó B, Bene J, Polgár N, Lakner L, Sarlós P, Varga M, Melegh B. Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients. World J Gastroenterol 2010; 16(2): 176-183
URL: https://www.wjgnet.com/1007-9327/full/v16/i2/176.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i2.176