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World J Gastroenterol. May 21, 2010; 16(19): 2435-2439
Published online May 21, 2010. doi: 10.3748/wjg.v16.i19.2435
Published online May 21, 2010. doi: 10.3748/wjg.v16.i19.2435
Study | Country | Study type | Severity of alcoholic hepatitis | Placebo size | Mean age | Gender (M/F) | Active therapy | Therapeutic time | Follow-up time | Death (1-mo/overall) |
Helman et al[24], 1971 | US | Single center | Unclassified | 17 | 47.7 | NA | Prednisolone | 4 wk | 3 mo | NA/6 |
Blitzer et al[25], 1977 | US | Single center | Unclassified | 16 | 48.4 | NA | Prednisolone | 26 d | 9 wk | NA/5 |
Maddrey et al[26], 1978 | US | Single center | Moderate to severe | 31 | 42.3 | 23/8 | Prednisolone | 28-32 d | 4 wk | 6/6 |
Baker et al[27], 1981 | US | Single center | Unclassified | 25 | 41.0 | 13/12 | Insulin/glucagon | 3 wk | 3 wk | NA/6 |
Hallé et al[28], 1982 | US | Single center | Severe | 36 | 38.9 | 32/4 | Propylthiouracil | 6 wk | 8 wk | 7/7 |
Mendenhall et al[29], 1984 | US | Multi-center | Moderate to severe | 88 | 50.4 | NA | Oxandrolone and prednisolone | 1 mo | 2 yr | NA/50 |
Fehér et al[30], 1987 | Hungary and Spain | Multi-center | Unclassified | 33 | 46.0 | 18/15 | Insulin/glucagon | 3 wk | 3 wk | NA/14 |
Carithers et al[31], 1989 | US | Multi-center | Severe | 31 | 44.4 | 21/10 | Methylprednisolone | 4 wk | 4 wk | 11/11 |
Trinchet et al[32], 1989 | Belgique | Multi-center | Unclassified | 34 | 52.0 | 17/17 | Colchicine | 6 mo | 6 mo | 0/0 |
Akriviadis et al[33], 1990 | US | Single center | Severe | 36 | 40.8 | 25/11 | Colchicine | 1 mo | 4 mo | 6/8 |
Panos et al[34], 1990 | UK | Single center | Unclassified | 51 | 49.3 | 22/29 | Polyunsaturated phosphatidyl choline | 2 yr | 2 yr | NA/20 |
Bird et al[35], 1991 | UK | Single center | Severe | 43 | 51.0 | 16/14 | Insulin/glucagon | 3 wk | 6 mo | 14/15 |
Mezey et al[36], 1991 | Spain | Multi-center | Severe | 26 | 43.7 | 12/14 | Amino acid suppl. | 3 wk | 23 mo | 5/16 |
Ramond et al[23], 1992 | France | Multi-center | Severe | 29 | 48.2 | 9/20 | Prednisolone | 4 wk | 6 mo | NA/16 |
Trinchet et al[37], 1992 | France | Multi-center | Severe | 35 | 48.0 | 17/18 | Insulin/glucagon | 3 wk | 1 mo | 5/5 |
Bird et al[38], 1998 | UK | Multi-center | Unclassified | 30 | 51.0 | 16/14 | Amlodipine | 4 wk | 4 wk | 7/7 |
Akriviadis et al[9], 2000 | US | Single center | Severe | 52 | 40.8 | 40/17 | Pentoxifylline | 4 wk | 160 d | NA/24 |
Mezey et al[39], 2004 | US and Spain | Multi-center | Unclassified | 26 | 49.0 | 16/10 | Vitamin E | 3 mo | 1 yr | NA/5 |
Boetticher et al[40], 2008 | US | Multi-center | Moderate to severe | 22 | 49.1 | 17/5 | Etanercept | 3 wk | 6 mo | 5/5 |
- Citation: Yu CH, Xu CF, Ye H, Li L, Li YM. Early mortality of alcoholic hepatitis: A review of data from placebo-controlled clinical trials. World J Gastroenterol 2010; 16(19): 2435-2439
- URL: https://www.wjgnet.com/1007-9327/full/v16/i19/2435.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i19.2435