Circulating microRNAs: Novel biomarkers for esophageal cancer

Table 1 Differential expression of miRNAs in EC tissues compared with normal tissue as identified in seven studies

Techniques	Pathology	Population	Overexpressed miRNAs			Underexpressed miRNAs		Ref.
Array profiling	ESCC	Chinese	hsa-miR-25	hsa-miR-424	has-miR-151	hsa-miR-100	hsa-miR-99a	[6]
						hsa-miR-29c	mmu-miR-140
mirVana miRNA Bioarrays (Ambion)	EAC	Japanese	miR-192	miR-194	miR-200c	miR-205	miR-203	[25]
			miR-21	miR-93
	ESCC	Japanese	miR-342	miR-21	miR-93	miR-205	miR-203
qRT-PCR	ESCC	Cell lines, Chinese	miR let-7d	miR-330	miR-340			[26]
			miR-373
qRT-PCR	ESCC	Japanese	miR-9	miR-15b	miR-16	miR-133a	miR-133b	[27]
			miR-17-5p	miR-20a	miR-20b	miR-139	miR-145
			miR-21	miR-25	miR-34b
			miR-34c	miR-103	miR-106a
			miR-107	miR-127	miR-129
			miR-130a	miR-130b	miR-132
			miR-134	miR-137	miR-138
			miR-151
Agilent Human miRNA microarray kit version 1.0	EAC	Caucasian	hsa-miR-126	hsa-miR-143	hsa-miR-145	hsa-miR-149	hsa-miR-203	[28]
			hsa-miR-146a	hsa-miR-181a	hsa-miR-181b	hsa-miR-205	hsa-miR-210
			hsa-miR-195	hsa-miR-28	hsa-miR-199b	hsa-miR-221	hsa-miR-27b
			hsa-miR-199a	hsa-miR-30a-5p	hsa-miR-29c	hsa-miR494	hsa-miR-513
			hsa-miR-424			hsamiR-617	hsa-miR-99a
miRNA microarray chips version 3	EAC	Caucasian	miR-21	miR-192		miR-203		[29]
			miR-194	miR-223
	ESCC	Japanese	miR-21			miR-375
qRT-PCR	ESCC	Cell lines, Chinese	miR-10					[30]

miRNAs: Micro ribonucleic acids; EC: Esophageal cancer; ESCC: Esophageal squamous cell carcinoma; EAC: Adenocarcinoma; qRT-PCR: Quantitative real-time polymerase chain reaction.