Expression of interleukin 6 in brain and colon of rats with TNBS-induced colitis

Figure 2 Assessment of TNBS-induced colitis rats by time points. As these severe inflammatory changes covered 2-4 cm of the distal colonic mucosa, this resulted in a higher median macroscopic damage score in TNBS-treated rats compared to controls (A, P < 0.01), especially by day 7; compared with the control rats, MPO activity increased gradually, peaked by day 7, and decreased to nearly the baseline value (B); The score reached a peak at day 7, and decreased gradually to nearly the normal value (C).