Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection

doi:10.3748/wjg.v16.i18.2265

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 18

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5715)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-4) series.

Item

Count

PDF

429

HTML

4801

Figures (1-1)

204

Tables (1-4)

281

Sum=5715

May 14, 2010 (publication date) through Feb 11, 2025

Times Cited of This Article

Times Cited (87)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. May 14, 2010; 16(18): 2265-2271
Published online May 14, 2010. doi: 10.3748/wjg.v16.i18.2265

Table 1 Comparison of baseline features among HBV, HCV, dual HBV and HCV, and non-HBV, non-HCV related hepatocellular carcinoma patients

	HBV n = 63	HCV n = 59	HBV + HCV n = 15	Non-HBV, non-HCV n = 28	P value
Age (yr)¹	55 (46-66)^a^c	66 (57-75)^a^d	60 (50-68)^d	61 (55-67)^c	< 0.001
Sex (M/F)	45/18	41/18	10/5	26/2	0.093
DM (%)	8 (12.7)^a	21 (35.6)^a^e	4 (26.7)	2 (7.1)^e	0.003
BMI (kg/m²)¹	24.3 (22.2-26.8)	23.8 (21.8-26.6)	23.6 (20.9-25.5)	24.5 (23.3-26.7)	0.439
Overweight (%)	24 (38)	22 (37)	4 (27)	10 (36)	0.797
Obesity (%)	4 (6)	5 (8)	1 (7)	2 (7)	0.965
AST (U/L)¹	48 (38-71)^a	72 (39-123)^a^e	72 (47-111)	38 (29-52)^e	0.002
ALT (U/L)¹	45 (34-63)^a	63 (29-100)^a^e	82 (54-117)	27 (21-39)^e	0.011
Child–Pugh class (A/B, C)	47/16	46/13	11/4	23/5	0.857
Platelet (10⁴/μL)¹	16.5 (12.0-25.0)^a	13.2 (8.7-17.1)^a^e	12.7 (7.6-18.1)^f	21.1 (15.3-24.1)^e^f	0.001
AFP (ng/mL)¹	15 (6-525)	28 (7-256)	38 (11-4388)	15 (6-8027)	0.468
Tumor size ( ≤ 3 cm) (%)	14 (22.2)^a	29 (49.2)^a^e	7 (46.7)	5 (17.9)^e	< 0.001
BCLC ( ≤ early stage) (%)	20 (31.7)^a^b	31 (52.5)^a^e^f	9 (60.0)^b	4 (14.3)^e^f	0.001
HOMA-IR	3.5 (2.0-8.6)^a	4.4 (2.9-6.6)^a	3.2 (1.7-10.7)	3.4 (2.0-4.6)	0.108
Insulin (μU/mL)¹	12.8 (8.4-25.0)	14.8 (9.9-21.30)	11.9 (8.1-23.5)	9.7 (7.6-14.8)	0.256
Adiponectin (μg/mL)	4.7 (2.9-8.1)^a^c	7.9 (5.2-11.0)^a^e	8.0 (3.8-10.9)^f	3.7 (2.0-6.0)^c^e^f	0.002

¹Median (interquartile range); P value by one-way ANOVA test or χ² test;

^aP < 0.05 between HBV and HCV;

^bP < 0.05 between HBV and HBV + HCV;

^cP < 0.05 between HBV and non-HBV, non-HCV;

^dP < 0.05 between HCV and HBV + HCV;

^eP < 0.05 between HCV and non-HBV, non-HCV;

^fP < 0.05 between HBV + HCV and non-HBV, non-HCV HCC with LSD post-hoc correction. HBV: Hepatitis B virus; HCV: Hepatitis C virus; DM: Diabetes mellitus; BMI: Body mass index; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; AFP: Alpha-fetoprotein; BCLC: Barcelona clinic liver cancer; HOMA-IR: Homeostasis model assessment of insulin resistance.

Citation: Hung CH, Wang JH, Hu TH, Chen CH, Chang KC, Yen YH, Kuo YH, Tsai MC, Lu SN, Lee CM. Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection. World J Gastroenterol 2010; 16(18): 2265-2271
URL: https://www.wjgnet.com/1007-9327/full/v16/i18/2265.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i18.2265