Cost-utility of molecular adsorbent recirculating system treatment in acute liver failure

Table 3 Baseline data for the MARS and control groups

	MARS group	Historical control group	P value
Pre-treatment demographic & clinical data
Number of patients	90	17
Age (yr)	45 (14-81)	42 (21-72)	0.714
Sex (male)	37 (41%)	7 (41%)	0.996
Body mass index (kg/m2)	26 (17-40)	26 (21-37)	0.372
MARS sessions/patient	2 (1-9)	0
Mechanically ventilated	30 (33%)	6 (35%)	0.875
Vasoactive infusion used	27 (30%)	9 (56%)	0.041
Renal insufficiency	29 (32%)	7 (41%)	0.474
MELD-score	31 (5-50)	30 (19-51)	0.225
Mean encephalopathy grade	1.7 ± 1.6	2.1 ± 1.7	0.335
Contra-indication to Ltx prior to treatment	11 (12%)	4 (24%)	0.253
Became untransplantable during treatment	7 (8%)	3 (18%)	0.195
Number of transplanted patients	26 (29%)	8 (47%)	0.162
Pre-treatment key laboratory values
Platelets (× 109/L)	138 (11-410)	142 (51-448)	0.919
NH4 ion (μmol/L)	68 (8-512)	90 (14-241)	0.559
Bilirubin (μmol/L)	215 (4-761)	381 (38-880)	0.057
Creatinine (μmol/L)	75 (35-1318)	78 (38-275)	0.946
FV (%)	32 (5-142)	38 (7-71)	0.865

All values are expressed as median (range) or as number of patients (%). Hepatic encephalopathy grade is presented as mean ± SD. MELD score: Mean end-stage liver disease score; Ltx: Liver transplantation; FV: Coagulation factor V.