Serum response factor: Look into the gut

Table 2 Tools and models available to study SRF functions in GI

Tool	Purpose	Model
SRF in pcDNA3.1, His[6,21]	SRF over-expression	Gene therapy
SRF antisense sequence[21,33]	SRF down-regulation (siRNA)	Gene depletion
Srf Flex1 mice[35]	Conditional in vivo SRF deletion	Gene depletion
Srf loxP mice[30]	Conditional in vivo SRF deletion	Gene depletion
CreER T2 mice[36]	SMS tissue expression	CIPO
AlfpCre mice[31]	Hepatocyte tissue expression	Liver function
K5-Cre mice[37]	Squamous epithelial expression	Esophagus, foregut
Fabp/Cre mice[38]	Conditional gut tissue expression	Small/large intestine
H. pylori[23]	H. pylori infection in human cell lines (in vitro) or mice (in vivo)	H. pylori gastric diseases