Inhibition of hepatitis C virus replication by single-stranded RNA structural mimics

Figure 1 Predicted folding of RNA sequences designed as mimics of hepatitis C virus (HCV) genotype 1b regions. HCV RNA sequences were predicted by Mfold ver 3.2 to adopt stem-loop structures identical to the corresponding sequences in full-length viral RNA. A: 5B-74 corresponding to NS-5B (+) strand; B: BA region 3’-terminus of (-) strand; C: EC region 3’-terminus of (-) strand; D: X region of (+) strand.