Effect of oxymatrine on the replication cycle of hepatitis B virus in vitro

doi:10.3748/wjg.v16.i16.2028

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Apr 28, 2010 (publication date) through Jul 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2010; 16(16): 2028-2037
Published online Apr 28, 2010. doi: 10.3748/wjg.v16.i16.2028

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Figure 5 Effect of oxymatrine on the replication of HBV in HepG2. 2.15 cell line after treatment for 2 d and 5 d. Compared to normal control, treatment with oxymatrine for 2 d and 5 d resulted in: (A) a decrease in HBV DNA in the supernatant by 40.75% and 75.32%, respectively; (B) a reduction in the intracellular HBV cccDNA pool by 63.98% and 80.83%; and (C) a reduction in viral DNA in the intracellular core particles by 34.35% and 39.24%. However, intracellular pgRNA increased by 6.90-fold and 3.18-fold (D).

Citation: Xu WS, Zhao KK, Miao XH, Ni W, Cai X, Zhang RQ, Wang JX. Effect of oxymatrine on the replication cycle of hepatitis B virus in vitro. World J Gastroenterol 2010; 16(16): 2028-2037
URL: https://www.wjgnet.com/1007-9327/full/v16/i16/2028.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i16.2028