Application of hepatitis B virus replication mouse model

Figure 1 Evaluation of the effect of polyIC on hepatitis B virus (HBV) replication using the HBV replication mouse model. A: The effect of polyIC on HBV DNA replication intermediates in mouse model. After hydrodynamic transfection, mice were treated with phosphate-buffered saline (PBS) (control) or polyIC; B: The relative intensity of HBV DNA replication intermediates of the mouse model for PBS group and polyIC group which inhibited the HBV replication by about one fold. The levels of HBV DNA replication intermediates in PBS-treated group were set to 1, and the relative levels of polyIC-treated group were calculated accordingly.