LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma

Table 2 Representative clinicopathologic correlation of LOH in different genes around D4S2964

Parameter	LOH
	Absent	Present	P value
Tumor size (cm)	ART3a
≤ 5	16	3	0.043
> 5	39	27
Tumor size (cm)	NUP54
≤ 5	15	6	0.019
> 5	30	41
Tumor size (cm)	SCARB2
≤ 5	18	3	0.001
> 5	33	39
Tumor size (cm)	CCDC158
≤ 5	11	3	0.037
> 5	19	22
Serum HBeAg	SEPT11
Negative	50	32	0.041
Positive	4	9
Serum HBsAg	CCNI
Negative	11	1	0.037
Positive	48	31
Serum HBeAg	CXCL13
Negative	50	37	0.024
Positive	2	8
Recurrence
No	40	26	0.044
Yes	12	19
Tumor stage	ANXA3
I and II	37	29	0.014
III and IV	15	2
Serum HBV-DNA	ARD1B
Negative	24	5	0.049
Positive	14	10
Recurrence
No	32	9	0.046
Yes	7	7
Serum HBsAg	SEC31A
Negative	4	10	0.013
Positive	47	26
Metastasis
No	40	34	0.039
Yes	11	2
Cirrhosis	HELQ
Absent	8	0	0.006
Present	32	34
Cirrhosis	AGPAT9
Absent	7	3	0.033
Present	27	50

^aGenes are listed in order of the most centromeric (top) to the most telomeric (bottom). LOH: Loss of heterozygosity; HBV: Hepatitis B virus; ART3: ADP-ribosyltransferase 3; NUP54: Nucleoporin 54 kDa; SCARB2: Scavenger receptor class B, member 2; CCDC158: Coiled-coil domain containing 158; SEPT11: Septin 11; CCNI: Cyclin I; CXCL13: Chemokine (C-X-C motif) ligand 13; ANXA3: Annexin A3; SEC31A: SEC31 homolog A; HELQ: Helicase, POLQ-like; AGPAT9: 1-acylglycerol-3-phosphate O-acyltransferase 9.