Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity

Table 3 Binding capacity, cytotoxicity and antagonicity of HCV NS3 peptides

Sequence	Name	Peptide origin	Position	Peptide length (aa)	IC50 (nmol/L)	R2	Cytotoxicity 10 nmol/L (%)1	Inhibition1:1 (%)
CINGVCWTV	Wt1073	HCV NS3	1073-1081	9	54 640	0.994	86.74	-
CINGVSWTV	C1078S	HCV NS3	wt1073 (C6S)	9	1271	0.993	24.57	59.30
YINGVCWTV	C1073Y	HCV NS3	wt1073 (C1Y)	9	1627	0.999	45.21	44.70
CINGVCRTV	W1079R	HCV NS3	wt1073 (W7R)	9	297 500	0.991	21.02	54.50
YLVTRHADV	Wt1131	HCV NS3	1131-1139	9	4800	0.995	52.03	-
YLVMRHADV	T1134M	HCV NS3	wt1131 (T4M)	9	7200	0.991	44.53	36.75
YLVTRYADV	H1136Y	HCV NS3	wt1131 (H6Y)	9	7401	0.993	35.56	92.54
CLVTRHADV	Y1131C	HCV NS3	wt1131 (Y1C)	9	8345	0.995	2.01	67.89
YLVTRRADV	H1136R	HCV NS3	wt1131 (H6R)	9	27 700	0.993	14.53	47.46
LLCPAGHAV	Wt1169	HCV NS3	1169-1177	9	35 440	0.999	84.56	-
LLCPAGHTV	A1176T	HCV NS3	wt1169 (A8T)	9	27 640	0.998	27.75	61.42
LLRPAGHAV	C1171R	HCV NS3	wt1169 (C3R)	9	82 100	0.997	59.98	44.39
FLPSDFFPSV	HBV-Core	HBV Core	(18-27)[99]	10	481.1	0.999	NS	NS
SLYNTVATL	HIV-p17	HIV-1 p17	(77-85)[100]	9	4248	0.984	NS	NS
ILKEPVHGV	HIV-RT	HIV-1 Pol	(476-484)[47]	9	7082	0.997	NS	NS

¹Means of two experiments. Variant substitutions are expressed in underlined letters.