Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension

Figure 5 nNOS- and HSP-90-mediated neuronal vasorelaxation in PVL and sham rats. PNS-induced nitrergic vasorelaxation in de-endothelialized mesenteric vasculature is depicted before and after L-NAME (A) as well as before and after HSP-90-inhibition with geldanamycin (B). It can be appreciated that no more significant differences in frequency-dependent neuronal vasorelaxation were observed between the study groups after L-NAME as well as after geldanamycin. Values given as mean ± SE. PVL-group: n = 6; Sham group: n = 6. P < 0.05 for ANOVA comparing study groups. Elect. nerve stimulation: Electric nerve stimulation; NS: Not significant.