Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients

Table 2 Univariate analysis to identify factors predictive of LDA-associated gastroduodenal ulcer in male and female patients

Factor	Male patients (n = 299)			Female patients (n = 155)
	Patients with ulcer (n = 87)	Patients without ulcer (n = 211)	P-value	Patients with ulcer (n = 32)	Patients without ulcer (n = 123)	P-value
PPIs	1	22	0.0038	0	18	0.0253
H2RAs	16	53	NS	5	38	NS
Muco-protective agents	18	40	NS	6	18	NS
Hypertension	62	150	NS	21	88	NS
Hyperlipidemia	36	96	NS	14	51	NS
History of peptic ulcer	18	19	0.0109	9	9	0.0030
Diabetes mellitus	29	63	NS	11	30	NS
Insulin therapy	4	12	NS	3	3	NS
Anticoagulants	29	87	NS	11	35	NS
NSAIDs	3	25	NS	3	10	NS
Age ≥ 70 yr	45	123	NS	28	85	0.0443
Alcohol	28	63	NS	6	12	NS
Smoking	22	36	NS	1	8	NS

PPIs: Proton-pump inhibitors; H2RAs: Histamine type 2 receptor antagonists; NSAIDs: Nonsteroidal anti-inflammatory drugs.