Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients

Table 1 Clinical characteristics of patients taking LDA enrolled in the present study

	Patients with ulcer (n = 119)	Patients without ulcer (n = 334)	P-value
Gender (male/female)	87/32	211/123	NS
Age (yr), median (range)	73.0 (47-92)	72.0 (45-95)	NS
Male (n = 298)	70.0 (47-92)	71.0 (43-93)	NS
Female (n = 155)	77.0 (54-92)	73.0 (47-95)	0.0338
Underlying disease (male/female)
Ischemic heart disease	77 (61/16)	205 (131/74)	NS
Cerebral infarction	22 (10/12)	70 (39/31)	NS
Atrial fibrillation	16 (13/3)	43 (28/15)	NS
Others	4 (3/1)	16 (13/3)	NS
Symptoms (male/female)
Melena, hematemesis	46 (29/17)	1 (0/1)	< 0.0001
GI symptoms	31 (21/10)	107 (72/35)	NS1
Anemia	17 (14/3)	40 (21/19)	0.0156
Body weight loss	1 (1/0)	7 (5/2)	0.0087
Appetite loss	1 (1/0)	8 (2/6)	0.0028
None (medical check)	18 (15/3)	146 (96/50)	0.0025
Others	5 (2/0)	25 (15/10)	> 0.9999
Helicobacter pylori	62.3% (43/69)	-
Male	66.7% (30/45)	-
Female	54.2% (13/24)	-

¹Forty-six patients presented with melena and/or hematemesis and bleeding source in the stomach or duodenum identified by endoscopy and were excluded from GI symptoms in this analysis. LDA: Low-dose aspirin; GI: Gastrointestinal; NS: Not significant.