NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn’s disease

Table 3 Genotype and allele frequencies of ATG16L1 polymorphism rs2241880 and IL23R polymorphism rs11209026 in childhood-onset CD patients, adult-onset CD, and controls n (%)

	Childhood-onset CD (n = 110)	Adult-onset CD (n = 364)	Controls (n = 539)
rs2241880
Genotype
AA	17 (15.45)	46 (12.64)	104 (19.30)
AG	45 (40.91)	177 (48.63)	274 (50.83)
GG	48 (43.64)	141 (38.74)	161 (29.90)
P value1	0.0190
P value2	NS
P value3		0.0040
G allele	141 (64.09)	459 (63.05)	596 (55.29)
P value1, OR (95% CI)	0.0170, 1.44 (1.07-1.95)
P value2, OR (95% CI)	NS
P value3, OR (95% CI)		0.0010, 1.38 (1.14-1.67)
rs11209026
Genotype
RR	105 (95.45)	329 (90.38)	458 (84.97)
RQ	5 (4.54)	32 (8.79)	79 (14.66)
QQ	0	3 (0.82)	2 (0.37)
P value1	0.0120
P value2	NS
P value3		0.0220
Q allele	5 (2.27)	38 (5.22)	83 (7.69)
P value1, OR (95% CI)	0.0018, 0.28 (0.11-0.69)
P value2, OR (95% CI)	NS
P value3, OR (95% CI)		0.0400, 0.66 (0.44-0.98)

¹Childhood-onset vs controls;

²Childhood-onset vs adult onset;

³Adult onset vs controls.