NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn’s disease

Table 2 Genotype and allele frequencies of NOD2/CARD15 polymorphisms in childhood-onset CD patients, adult-onset CD, and controls n (%)

	Childhood-onset CD (n = 110)	Adult-onset CD (n = 364)	Controls (n = 539)
R702W
Genotype
CC	94 (85.45)	300 (82.40)	482 (89.40)
CT	14 (12.72)	62 (17.00)	55 (10.20)
TT	2 (1.81)	2 (0.55)	2 (0.37)
P value1	NS
P value2	NS
P value3		0.0260
T allele	18 (8.18)	66 (9.10)	59 (5.47)
P value1, OR (95% CI)	NS
P value2, OR (95% CI)	NS
P value3, OR (95% CI)		0.0040, 1.72 (1.19-2.48)
G908R
Genotype
GG	91 (82.73)	295 (81.00)	468 (86.83)
GC	17 (15.45)	65 (18.00)	69 (12.80)
CC	2 (1.81)	4 (1.00)	2 (0.37)
P value1	NS
P value2	NS
P value3		0.0420
C allele	21 (9.54)	73 (10.00)	73 (6.77)
P value1, OR (95% CI)	NS
P value2, OR (95% CI)	NS
P value3, OR (95% CI)		0.0140, 1.53 (1.09-2.15)
3020insC
Genotype
-	78 (70.90)	301 (82.69)	503 (93.32)
insC/-	28 (25.45)	57 (15.66)	35 (6.49)
insC/insC	4 (3.64)	6 (1.65)	1 (0.18)
P value1	< 0.0001
P value2	0.0200
P value3		< 0.0001
insC allele	36 (16.36)	69 (9.47)	37 (3.43)
P value1, OR (95% CI)	< 0.0001, 5.5 (3.39-8.94)
P value2, OR (95% CI)	0.0067, 1.87 (1.21-2.88)
P value3, OR (95% CI)		< 0.0001, 2.95 (2.04-4.44)

¹Childhood-onset vs controls;

²Childhood-onset vs adult onset;

³Adult onset vs controls. NS: Not significant.