Melatonin and Doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines

Figure 3 Effects of Melatonin and/or Doxorubicin on apoptosis of Bel-7402. A: Morphological changes of Bel-7402 cells treated with Mel and Dox. a: Untreated cells; b: 10^-5 mol/LMel; c: 2.5 mg/L Dox; d: 10^-5 mol/L Mel plus 2.5 mg/L Dox; B: Percentage of apoptotic cells by TUNEL test. Data are presented as mean ± SD (error bar) of triplicate cultures. ^eP < 0.05, ^fP < 0.01 vs control, ^hP < 0.01 vs Dox treated alone; C: Apoptotic cells determined by FCM assay. a: Untreated cells; b: 10^-5 mol/L Mel; c: 2.5 mg/L Dox; d: 10^-5 mol/L Mel plus 2.5 mg/L Dox.