Melatonin and Doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines

Figure 2 Effects of Melatonin and/or Doxorubicin on apoptosis of HepG2. A: Morphological changes of HepG2 cells treated with Mel and Dox. a: Untreated cells; b: 10^-5 mol/L Mel; c: 1.25 mg/L Dox; d: 10^-5 mol/L Mel plus 1.25 mg/L Dox; B: Percentage of apoptotic cells by TUNEL assay. Data are presented as mean ± SD (error bar) of triplicate cultures. ^fP < 0.01 vs control, ^hP < 0.01 vs Dox treated alone; C: Apoptotic cells determined by FCM assay. a: Untreated cells; b: 10^-5 mol/L Mel; c: 1.25 mg/L Dox; d: 10^-5 mol/L Mel plus 1.25 mg/L Dox.