Melatonin and Doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines

Figure 1 Synergistic effects and CDI of Melatonin and Doxorubicin on HepG2 and Bel-7402 cells. HepG2 cells (A) and Bel-7402 cells (C) were treated with 10^-8, 10^-7, 10^-6 and 10^-5 mol/L Melatonin and 0.31, 0.63, 1.25 and 2.50 g/L Doxorubicin for 48 h; CDI values of the combination group in HepG2 cells (B) and Bel-7402 cells (D). Data are presented as mean ± SE (error bar) of triplicate cultures. ^aP < 0.05, ^bP < 0.01 vs Dox treated alone.