Nonalcoholic steatohepatitis-associated hepatocellular carcinoma: Our case series and literature review

Table 1 Characteristics of 11 NASH patients with HCC undergoing curative treatment

Case	1	2	3	4	5	6	7	8	9	10	11
Sex (M/F)	M	F	F	M	M	M	F	F	F	F	M
Age (yr)	73	73	83	75	67	68	77	79	73	76	68
BMI	25.0	23.6	21.0	22.3	25.3	24.2	28.1	25.3	23.4	28.8	26.2
Diabetes mellitus (yes/no)	No	Yes	Yes	Yes	No	Yes	Yes	No	No	No	Yes
Dyslipidemia (yes/no)	No	Yes	No	Yes	No	No	No	No	No	No	Yes
Hypertension (yes/no)	No	Yes	No	Yes	Yes	No	Yes	Yes	No	No	Yes
Total bilirubin (mg/dL)	1.6	0.6	0.6	0.7	1.4	0.8	0.8	1.2	0.6	1.3	0.9
Albumin (g/dL)	3.9	4.4	3.2	3.8	4.4	4.3	3.5	4.1	4.4	3.8	4.9
ALT (IU/L)	73	41	22	24	73	18	19	29	41	40	57
γGTP (IU/L)	110	45	36	22	57	33	26	111	124	41	177
Prothrombin time (%)	78.1	95.8	96.3	106.6	90.9	113.4	75.4	77.2	94.0	68.4	86.0
Platelets (× 104/μL)	10.1	15.0	15.1	27.8	14.3	27.2	9.3	13.9	13.0	5.5	13.4
Child-Pugh classification (A/B)	A	A	A	A	A	A	B	A	A	A	A
AFP (ng/mL)	8.7	4.6	40.6	9181.6	1.7	1.8	1957.0	7.9	13.0	8.8	16.2
DCP (mAU/mL)	31	10	2066	1765	64	10	718	19	571	106	2930
Anti-HBc (+/-)	+	-	-	-	-	+	-	-	-	+	-
Treatment (RFA/MCT/Ope)	RFA	RFA	Ope	Ope	Ope	Ope	Ope	Ope	RFA	MCT	Ope
No. of nodules (1/2/3)	3	1	1	1	1	1	1	1	3	2	1
Size of largest tumor (cm)	1.8	1.7	5.0	5.0	3.6	4.5	3.2	2.0	2.5	3.0	4.4
Stage of fibrosis (F1/F2/F3/F4)	F4	F1	F4	F1	F1	F1	F4	F4	F1	F3	F1

NASH: Nonalcoholic steatohepatitis; HCC: Hepatocellular carcinoma; M: Male; F: Female; BMI: Body mass index; ALT: Alanine aminotransferase; γGTP: γ-glutamyltransferase; AFP: α-fetoprotein; DCP: Des-γ-carboxy prothrombin; Anti-HBc: HBc antibody; RFA: Radio-frequency ablation; MCT: Microwave coagulation therapy; Ope: Operation.