Impact of alcohol on hepatitis C virus replication and interferon signaling

doi:10.3748/wjg.v16.i11.1337

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Mar 21, 2010 (publication date) through Jan 6, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2010; 16(11): 1337-1343
Published online Mar 21, 2010. doi: 10.3748/wjg.v16.i11.1337

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Figure 1 Proposed model of hepatitis C virus (HCV)/alcohol interactions in hepatocytes. Metabolism of alcohol by cytochrome P450-2E1 (CYP2E1) and HCV replication leads to a synergistic induction of oxidative stress in the cell. Oxidative stress inhibits interferon (IFN)-α signalling and also leads to increased rates of inflammation, cirrhosis, and hepatocellular carcinoma (HCC). NS5A: Non-structural 5A; NF-κB: Nuclear factor κB; ROS: Reactive oxygen species.

Citation: McCartney EM, Beard MR. Impact of alcohol on hepatitis C virus replication and interferon signaling. World J Gastroenterol 2010; 16(11): 1337-1343
URL: https://www.wjgnet.com/1007-9327/full/v16/i11/1337.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i11.1337