Interferon-α induced severe thrombocytopenia: A case report and review of the literature

Table 1 Clinical characteristics of IFN-α-induced severe thrombocytopenia

Report source	Sex/age (yr)	Liver disease/treatment	HCV genotype/serotype	Baseline/Lowest PLTs ( × 103/mL)	Duration of IFNαtreatment	Bleeding tendency	Antiplatelets antibodies/PAIgG	Mgk in bone marrow	Treatment	Outcome
Shrestha et al[8]	M/41	HCV/IFNα	NR	6	NR	Yes	Negative	Increased	NR	CR
Dourakis et al[9]	M/39	HCV/IFNα	NR	→/14	8 mo	Yes	NR	Increased	Steriods/IvIg	CR
Dourakis et al[9]	F/64	HCV/IFNα	NR	→/10	6 mo	Yes	Positive	Increased	Steriods/IvIg	CR
Tappero et al[10]	F/NR	HCV/IFNα2a	NR	→/11	2 mo	NR	NR	NR	Steriods	CR
Jiménez-Sáenz et al[11]	M/46	HCV/IFNα2b	NR	→/3	3 yr	Yes	Positive	Increased	Steriods/IvIg	CR
Pockros et al[12]	M/61	HCV/IFNα	1b	→/9	4 mo	Yes	Positive	NR	Steriods	CR
Sagir et al[13]	M/45	HCV/Peg-IFNα2b	NR	147/9	10 wk	Yes	Negative	Increased	Steriods	CR
Sevastianos et al[14]	F/38	HCV, compensated cirrhosis/Peg-IFN2b	Group 4	141/5	4 wk	Yes	Positive	Increased	Steriods/IvIg	CR
Fujii et al[15]	F/24	HCV/IFNα	NR	→/1.1	4 wk	Yes	Positive	Increased	Steriods/IvIg	CR
Dimitroulopoulos et al[16]	F/20	HCV/IFNαcon-1	3a	→/11	28 wk	No	Positive	Increased	Steriods/IvIg	CR
Medeiros et al[17]	M/40	HCV/IFNα /PegIFNα2a	NR	→/6	6 mo	Yes	Positive	No performed	Steriods/IvIg	CR
Nakajima et al[4]	M/47	HCV/IFNα2a	1b	75/18	8 wk	Yes	Positive	Increased	IFN Discontinued	Not CR
Lambotte et al[18]	F/73	HCV/Peg-IFNα2a	1b	100/4	2 mo	Yes	Positive	Peripheral origin of the pancytopenia	Steriods/IvIg/PT	CR
Demirtur et al[19]	F/40	HCV/Peg-INF	NR	217/6	13 wk	Yes	Positive	Increased	Danazol/IvIg	CR
Elefsiniotis et al[20]	M/27	HCV/Peg-IFNα2b	NR	150/10	48 wk (6 mo after IFN discontinued)	Yes	Positive	Increased	Steriods	CR
Alves Couto et al[21]	M/44	HCV/Peg-IFNα2b	Group 3	164/2	16 wk	No	Negative	Increased	Steriods	CR
Our hospital	F/54	HCV/Peg-IFNα2a	1b	100/1	3 mo	Yes	Positive	Increased	Steriods/IvIg/PT	CR

F: Female; M: Male; IFN: Interferon; Peg: Pegylated; NR: Not reported; →: Normal; PAIgG: Platelet associated IgG; Mgk: Megakaryocytosis; IvIg: Intravenous Immunoglobulin; PT: Platelets transfusion; CR: Completed resolved.