Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application

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Mar 14, 2010 (publication date) through Jan 8, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2010; 16(10): 1267-1273
Published online Mar 14, 2010. doi: 10.3748/wjg.v16.i10.1267

Table 1 Sensitivity and specificity of the new method for the detection of ADV-associated HBV quasispecies

Plasmid	HBV DNA reagent	rtA181 reagent	rtN236 reagent
Wild strain plasmid of Type B	7.27E+06	-	-
Wild strain plasmid of Type C	7.23E+06	-	-
rtA181V variant plasmid	8.78E+06	1.88E+06	-
rtA181T variant plasmid	1.14E+07	2.26E+06	-
rtN236T variant plasmid of Type B	1.14E+07	-	1.25E+06
rtN236T variant plasmid of Type C	1.12E+07	-	1.31E+06
Mixed variants plasmid	5.92E+06	2.00E+06	1.18E+06

ADV: Adefovir; HBV: Hepatitis B virus.

Citation: Zhao WF, Shao YL, Chen LY, Wu JH, Zhu YL, Gan JH, Xiong H. Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application. World J Gastroenterol 2010; 16(10): 1267-1273
URL: https://www.wjgnet.com/1007-9327/full/v16/i10/1267.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i10.1267