Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer

Table 4 Evaluation of risks for advanced cancer

	Criteria	(Case/Cont)		Univariate analysis OR (95% CI)	P value	Multivariate analysis OR (95% CI)	P value
		Low	High
BMI (kg/m2)	< 22.5, ≥ 22.5	8/14	8/10	1.400 (0.392-4.997)	0.604
BP-S (mmHg)	< 120, ≥ 120	6/14	10/12	1.944 (0.545-0.940)	0.306
BP-D (mmHg)	< 80, ≥ 80	5/19	11/8	4.950 (1.289-19.014)	0.020a	5.015 (1.159-21.696)	0.031a
Glucose (mg/dL)	<100, ≥ 100	6/15	10/10	2.333 (0.638-8.538)	0.201
Insulin (μU/mL)	< 4.5, ≥ 4.5	5/12	11/14	1.885 (0.510-6.978)	0.342
HOMA-IR	< 2, ≥ 2	10/15	6/9	1.000 (0.271-3.694)	1.000
T-cho (mg/dL)	< 180, ≥ 180	7/13	9/10	1.671 (0.462-6.051)	0.434
TG (mg/dL)	< 120, ≥ 120	10/19	6/4	2.850 (0.650-12.505)	0.165
hsCRP (ng/mL)	< 500, ≥ 500	5/16	11/10	3.520 (0.941-13.174)	0.062	4.184 (0.896-19.529)	0.069
IGF-1/IGFBP-3	< 60, ≥ 60	7/14	9/11	1.753 (0.499-6.165)	0.382
Adiponectin (μg/mL)	< 11, ≥ 11	11/12	5/14	2.567 (0.644-9.498)	0.158	3.355 (0.729-15.451)	0.120
Leptin (ng/mL)	< 3, ≥ 3	11/13	5/13	0.455 (0.123-1.680)	0.237
Resistin (ng/mL)	< 42, ≥ 42	9/12	7/14	0.667 (0.190-2.334)	0.526

The OR (High vs Low) was evaluated by univariate and multivariate logistic regression analysis. Only the OR of adiponectin was inversely evaluated (Low vs High). Multivariate analysis included age, BP-D, hsCRP, and adiponectin.

^aP < 0.05.