Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer

Table 3 Evaluation of risks for early cancer

	Criteria	(Case/Cont)		Univariate analysis OR (95% CI)	P value	Multivariate analysis OR (95% CI)	P value
		Low	High
BMI (kg/m2)	< 22.5, ≥ 22.5	8/14	24/10	4.200 (1.344-13.128)	0.014a	2.814 (0.746-10.620)	0.127
BP-S (mmHg)	< 120, ≥ 120	11/14	22/12	2.333 (0.810-6.718)	0.116	1.702 (0.461-6.281)	0.425
BP-D (mmHg)	< 80, ≥ 80	21/18	12/8	1.286 (0.431-3.839)	0.653
Glucose (mg/dL)	<100, ≥ 100	15/14	18/10	1.680 (0.581-4.859)	0.338
Insulin (ng/mL)	< 4.5, ≥ 4.5	12/13	21/14	1.500 (0.526-4.276)	0.448
HOMA-IR	< 2, ≥ 2	13/15	17/9	1.771 (0.606-5.173)	0.296
T-cho (mg/dL)	< 180, ≥ 180	13/15	18/8	1.560 (0.534-4.557)	0.416
TG (mg/dL)	< 120, ≥ 120	18/19	15/4	3.958 (1.103-14.201)	0.035a	2.705 (0.596-12.283)	0.197
hsCRP (ng/mL)	< 500, ≥ 500	16/17	17/10	1.700 (0.598-4.830)	0.319
IGF-1/IGFBP-3	< 60, ≥ 60	18/15	15/11	1.136 (0.403-3.205)	0.809
Adiponectin (μg/mL)	< 11, ≥ 11	27/12	5/14	6.300 (1.847-21.485)	0.003b	4.495 (1.090-18.528)	0.038a
Leptin (ng/mL)	< 3, ≥ 3	8/14	24/13	3.000 (0.989-7.100)	0.052
Resistin (ng/mL)	< 42, ≥ 42	14/12	16/14	0.980 (0.324-2.808)	0.969

The OR (High vs Low) was evaluated by univariate and multivariate logistic regression analysis. Only the OR of adiponectin was inversely evaluated (Low vs High). Multivariate analysis included age, BMI, BP-S, TG, and adiponectin.

^aP < 0.05,

^bP < 0.01.