Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas

Table 3 Correlation of the GATA-4 and GATA-5 methylation status with their protein expression in sporadic gastric carcinomas with IHC

Protein expression, by IHC	GATA-4 methylation status			GATA-5 methylation status
	M	U	P-valuea	M	U	P-value
Positive (+ ~ +++)	7	11	0.012	5	9	0.011
Negative (- ~ ±)	11	3		16	3

IHC: Immunohistochemical staining; +~+++: 10% or more cancer cells exhibited a similar positive staining pattern; - or weak: Positive expression in less than 10% cancer cells or a weak staining pattern compared with a non-cancerous area of the same section; M: Methylated; U: Unmethylated;

^aFisher’s exact test by EpiInfo 6.0 software.