Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas

doi:10.3748/wjg.v16.i10.1201

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2010; 16(10): 1201-1208
Published online Mar 14, 2010. doi: 10.3748/wjg.v16.i10.1201

Table 2 GATA-4 and GATA-5 methylation frequency (%) in gastric dysplasia lesions in subjects from Linqu County, a high risk area for stomach cancer

Classification of gastric dysplasia	GATA-4	GATA-5
Low-grade noninvasive neoplasia	57.1 (16/28)	69.0 (20/29)
Hp-infection
With	71.4 (15/21)	63.6 (14/22)
Without	14.3 (1/7)^a	85.7 (6/7)
Indefinite for dysplasia^b	42.9 (30/70)	46.7 (35/75)^c
Total	46.9 (46/98)	52.9 (55/104)

^aχ² test by EpiInfo 6.0 software, with vs without Hp-infection, P = 0.023;

^bOnly two cases without Hp-infection;

^cχ² test by EpiInfo 6.0 software, Low-grade noninvasive neoplasia (GIN) vs indefinite for dysplasia, P = 0.042.

Citation: Wen XZ, Akiyama Y, Pan KF, Liu ZJ, Lu ZM, Zhou J, Gu LK, Dong CX, Zhu BD, Ji JF, You WC, Deng DJ. Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas. World J Gastroenterol 2010; 16(10): 1201-1208
URL: https://www.wjgnet.com/1007-9327/full/v16/i10/1201.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i10.1201