Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas

Table 1 Comparison of GATA-4 and GATA-5 methylation status with clinicopathological characteristics of SGC

Clinicopathological characteristics	Methylation positive rate (%)
	GATA-4		GATA-5
	SGC	N	SGC	N
SGC invasion
T1&T2 (n = 20)	45.0a	35.0b	45.0	45.0
T3 (n = 50)	54.0	42.0	68.0	48.0
T4 (n = 10)	70.0	50.0	60.0	40.0
Metastasis
Yes (n = 44)	52.3	31.8	61.4	36.4
No (n = 36)	55.6	52.8	61.1	38.9
H. pylori infection
Positive (n = 42)	61.9	45.2	64.3	50.0
Negative (n = 34)	41.2	38.2	55.9	44.1
Age (yr)
≤ 59 (n = 42)	45.2	33.3	57.1	28.6
≥ 60 (n = 38)	63.2	50.0	65.8	65.8c
Sex
Male (n = 62)	51.6	41.9	61.3	51.6
Female (n = 18)	61.1	38.9	61.1	27.6d
Total
n = 80	53.8	41.3	61.3	46.3e

SGC: Sporadic gastric carcinomas; N: Adjacent corresponding non-neoplastic gastric tissue; H. pylori: Helicobacter pylori detected by the 23S rRNA-PCR assay[16]; ^a,bAnalysis for linear trend by EpiInfo 6.0 software, positive rates vs extent of penetration of the stomach wall, P = 0.198 and 0.434, respectively;

^cχ² test by EpiInfo 6.0 software, samples from young patients (≤ 59 years old) vs old patients (≥ 60 years old), P < 0.001;

^dMale vs female, P = 0.074;

^eSGCs vs the normal, P = 0.057.