Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer

Table 3 Association of IL-6 polymorphism and gastroduodenal diseases

Position	Disease	Authors	Year		n
-174 C/G						C/C	C/G	G/G
	GC	Gatti et al[81]	2007	GC	56	1	13	42	GG: 11.0 (1.2-96.7)
				NUD	112	11	53	48
	GCC	Deans et al[82]	2007	GC	197	43	83	71	NS
				NUD	224	44	101	79
	GC	Kamangar et al[83]	2006	GC	102	27	54	21	GC: 2.2 (1.2-4.0) vs G/G
				NUD	152	43	58	51
	GC	El-Omar et al[53]	2003	GC	123	16	52	55	NS
				NUD	209	28	98	83
	GC	Hwang et al[77]	2003	GC	60	2	9	49	-
	PU	Chakravorty et al[84]	2008	GU	91	1	18	72	NS
				NUD	62	1	7	54
	DU	Hwang et al[77]	2003	DU	60	0	0	30	-
-572 G/C						C/C	C/G	G/G
	GC	Kang et al[85]	2009	GC	284	154	113	17	NS
				NUD	278	140	123	15
	GC	Hwang et al[77]	2003	GC	60	19	29	12	-
	PU	Kang et al[85]	2009	PU	434	249	167	20	DU: GG 0.3 (0.1-0.9)
				NUD	278	140	123	15
	PU	Chakravorty et al[84]	2008	PU	91	57	27	7	NS
				NUD	62	37	20	5
	DU	Hwang et al[77]	2003	DU	60	21	20	19	-
-597 G/A						G/G	G/A	A/A
	GC	Kamangar et al[83]	2006	GC	110	25	59	26	NS
				NUD	203	61	86	56
	GC	Hwang et al[77]	2003	GC	60	50	8	2	-
	PU	Chakravorty et al[84]	2008	PU	91	53	29	10	NS
				NUD	62	41	16	5
	DU	Hwang et al[77]	2003	GC	60	52	8	0	-
-634 C/T						C/C	C/T	T/T
	GC	Liao et al[72]	2008	GC	155	96	55	4	NS
				NUD	211	118	84	9

Although Kang et al and Savage et al investigated the association with IL-6-174 C/G polymorphism and gastric cancer, data were not described in detail (> 99% of patients were of the IL-6-174 G/G genotype).