Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer

Table 2 Association of IL-4 polymorphism and gastroduodenal diseases

Position	Disease	Authors	Year		n
-168 T/C						T/T	T/C	C/C
	GC	Wu et al[37]	2009	GC	1042	744	271	27	C carrier: 0.8 (0.7-1.0)
				NUD	1099	743	332	24
-590 C/T						C/C	C/T	T/T
	GC	Zambon et al[57]	2008	GC	40	32	7	1	NS
				NUD	171	124	43	4
	GC	García-González et al[56]	2007	GC	404	283	107	14	NS
				NUD	404	267	123	14
	GC	Lai et al[54]	2005	GC	123	83	38	2	NS
				NUD	162	105	50	7
	GC	El-Omar et al[53]	2003	GC	122	78	37	7	NS
				NUD	209	153	46	10
	GC	Wu et al[52]	2003	GC	220	146	69	5	C carrier (diffuse-type): 1.6 (1.0-2.7)
				NUD	230	163	55	12
	DU	Zambon et al[57]	2008	DU	171	124	43	4	NS
				NUD	107	79	26	2
	Atrophy	Kato et al[51]	2006	Atrophy	788	398	308	82	NS
				Dys	115	51	48	16
				NUD	1020	506	414	100
-33 C/T						C/C	C/T	T/T
	Atrophy	Togawa et al[34]	2005	Atrophy	157	10	70	77	T/C: 2.2 (1.0-4.9)
				NUD	452	42	183	227
984, 2983						AA/AA	AA/GC	AA/GA
	GC	Seno et al[55]	2007	Atrophy	100	52	29	7	AA/GA: 0.3 (0.1-0.9)
				NUD	93	40	27	17

Although Seno et al[55] investigated nine SNPs (IL-4-590, -33, 3437, 3557, 4047, 4144, 4271, 4367 and 8427), data concerning the exclusion of IL-4+984 and 2983 were unclear. Dys: Dysplasia; DU: Duodenal ulcer.