Atrial natriuretic peptide signal pathway upregulated in stomach of streptozotocin-induced diabetic mice

Figure 2 Immunohistochemical analysis of atrial natriuretic peptide (ANP) in mouse gastric tissue. The photographs show ANP expression in gastric mucosa in the control group (A), STZ-induced diabetic group (B), and negative control group (C); The paranuclear cytoplasmic stained cells that display an intense dark brown color were ANP-positive-staining cells in the mucosa. The red arrows indicate ANP-positive cells; B shows that the number of ANP-positive cells increased in the STZ-induced diabetic group; D shows the density index that referred to the number of ANP-positive cells per field of vision (n = 8, ^aP < 0.05 vs control group). Scale bar = 20 μm.