Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection

Table 1 Histological and serum findings in patients with mild to moderate (n = 9) and severe (n = 14) atrophic changes in the corpus

Findings	Number of patients with atrophic corpus gastritis						P-value
	Grade 1 or 2			Grade 3
	IB+ (n = 8)	IB- (n = 1)	Total	IB+ (n = 8)	IB- (n = 6)	Total
Chronic corpus gastritis	7	1	8	8	6	14	NS
Chronic antral gastritis	7	1	8	3	3	6	0.04
Antral intestinal metaplasia	3	0	3	0	0	0	0.05
H. pylori in histology	4	0	4	0	0	0	0.01
Elevated EIA H. pylori IgG1	7	0	7	0	0	0	0.0001
Vitamin B12 therapy	1	0	1	4	6	10	0.009
Elevated PCA2	2	1	3	8	4	12	0.02
Elevated IF antibodies3	0	1	1	4	4	8	0.04
Low pepsinogen I4	0	0	0	8	6	14	0.0001
Elevated pepsinogen II5	5	0	5	4	1	5	NS
Low pepsinogen I/II6	1	0	1	8	6	14	0.0001
Elevated gastrin-177	2	1	3	8	5	13	0.005

¹In-house EIA positive ≥ 700;

²Parietal cell antibodies PCA elevated > 15;

³Intrinsic factor IF elevated > 2;

⁴Pepsinogen I low < 30;

⁵Pepsinogen II elevated > 10;

⁶Pepsinogen I/II low < 3;

⁷Gastrin 17 elevated > 10. EIA: Enzyme immunoassay; H. pylori: Helicobacter pylori; PCA: Parietal cell antibodies; IF: Intrinsic factor; NS: Not significant; IB+: Immunoblot positive; IB-: Immunoblot negative. P-value: Total (grade 1 or 2) vs total (grade 3).