Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells

Figure 3 DHA suppresses AA- and PGE2-induced proliferation. A: DHA inhibited AA-induced proliferation, ^aP < 0.001. Results represent six independent experiments. B: PGE₂ formation was induced by AA treatment and was suppressed by concomitant DHA incubation, ^aP < 0.001, ^bP < 0.01. Results represent the mean of PGE₂ measurements from three independent samples. C: COX-2 transcription was activated by AA, but suppressed by DHA. ^cP < 0.05 versus control, ^bP < 0.01 versus control. Bars represent at least three experiments. D: DHA suppressed PGE₂-induced cell proliferation, ^cP < 0.05, ^bP < 0.01. Results represent five independent experiments.