Editorial
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Mar 7, 2009; 15(9): 1025-1034
Published online Mar 7, 2009. doi: 10.3748/wjg.15.1025
Table 2 Specific susceptibility genes in type 1 and type 2 autoimmune hepatitis
GenesPopulationType of AIHLinkage disequilibriumReferences
MHC genes
HLA-A1-B8North-America, Europe1Yes[1415]
HLA-DRB1*0301North-America, UK, Spain, Argentina1 and 2Yes[141525]
HLA-DRB1*0401North-America, EuropeND[1415]
HLA-DRB1*0404Mexico1ND[18]
HLA-DRB1*0405Argentina, Japan1-[1920]
HLA-DRB1*1301North-America, Europe, Brazil, Argentina1Yes[1621]
HLA-DRB1-07Germany, Brazil, UK2Yes[2324]
HLA-DRB3*01Brazil[2223]
HLA-DQB1*0201North-America, Europe2Yes[16]
HLA-DQB1*0603North-America, Europe2Yes[16]
Non-MHC genes
IgAEurope1[2829]
C4AEurope, North-America1 and 2Yes[3031]
CTLA4North-America, Europe1Yes[3536]
FasJapan, North-America1ND[3738]
Vitamin D receptorGermany1 and 2ND[39]
TNFa*2North-America, UK1Yes[4344]