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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Mar 7, 2009; 15(9): 1025-1034
Published online Mar 7, 2009. doi: 10.3748/wjg.15.1025
Published online Mar 7, 2009. doi: 10.3748/wjg.15.1025
Table 2 Specific susceptibility genes in type 1 and type 2 autoimmune hepatitis
Genes | Population | Type of AIH | Linkage disequilibrium | References |
MHC genes | ||||
HLA-A1-B8 | North-America, Europe | 1 | Yes | [1415] |
HLA-DRB1*0301 | North-America, UK, Spain, Argentina | 1 and 2 | Yes | [141525] |
HLA-DRB1*0401 | North-America, Europe | ND | [1415] | |
HLA-DRB1*0404 | Mexico | 1 | ND | [18] |
HLA-DRB1*0405 | Argentina, Japan | 1 | - | [1920] |
HLA-DRB1*1301 | North-America, Europe, Brazil, Argentina | 1 | Yes | [1621] |
HLA-DRB1-07 | Germany, Brazil, UK | 2 | Yes | [2324] |
HLA-DRB3*01 | Brazil | [2223] | ||
HLA-DQB1*0201 | North-America, Europe | 2 | Yes | [16] |
HLA-DQB1*0603 | North-America, Europe | 2 | Yes | [16] |
Non-MHC genes | ||||
IgA | Europe | 1 | [2829] | |
C4A | Europe, North-America | 1 and 2 | Yes | [3031] |
CTLA4 | North-America, Europe | 1 | Yes | [3536] |
Fas | Japan, North-America | 1 | ND | [3738] |
Vitamin D receptor | Germany | 1 and 2 | ND | [39] |
TNFa*2 | North-America, UK | 1 | Yes | [4344] |
- Citation: Béland K, Lapierre P, Alvarez F. Influence of genes, sex, age and environment on the onset of autoimmune hepatitis. World J Gastroenterol 2009; 15(9): 1025-1034
- URL: https://www.wjgnet.com/1007-9327/full/v15/i9/1025.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.1025