Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease

Table 3 Serum vitamin B6, folate, vitamin B12 and plasma homocysteine levels in patients with celiac disease without (Marsh 0-II) and with (Marsh III) villous atrophy

Variable	All patients with celiac disease (n = 51)			Patients with celiac disease not using vitamins (n = 26)			Patients with celiac disease using vitamins (n = 25)
	Marsh III (n = 26)	Marsh 0-II(n = 25)	Pvalue1	Marsh III(n = 14)	Marsh 0-II(n = 12)	Pvalue1	Marsh III (n = 12)	Marsh 0-II (n = 13)	Pvalue1
Median vitamin B6 (interquartile range), nmol/L	54.5	60.0	0.26	34.0	61.5	0.59	72.0	91.0	0.47
	20.7-99.7	33.0-170.5		20.7-71.2	23.5-96.5		17.2-165.0	45.0-238.0
Median folate (interquartile range), nmol/L	14.2	19.8	0.41	12.2	12.1	0.49	34.8	27.8	0.93
	7.2-33.9	11.5-28.9		6.2-16.1	7.7-19.1		11.7-75.4	18.6-36.1
Median vitamin B12 (interquartile range), pmol/L	263.0	278.0	0.45	229.0	254.5	0.52	455.5	317.0	0.04
	195.2-433.0	177.5-353.5		173.7-295.5	171.7-303.0		256.7-916.2	180.0-380.0
Median homocysteine (interquartile range), &mgr;mol/L	11.0	9.1	0.018	12.6	9.3	0.04	8.9	7.1	0.20
	8.1-16.1	6.7-10.7		10.5-17.4	9.1-13.4		6.1-13.2	6.1-8.8
Use of vitamin supplements, n%	12 (46.1%)	13 (52.0%)	0.782

¹Continuous data were compared by Kruskall-Wallis test;

²Vitamin use versus no vitamin use frequency was compared by Fisher’s exact test (two-sided).